24
4
2
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T2319 | Acotiamide monohydrochloride trihydrate | Acotiamide hydrochloride,YM-443 HCl,Z-338 HCl | AChE |
Acotiamide monohydrochloride trihydrate (Z-338 HCl) is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. Although the exact mechanism by which acotiamid... | |||
T31597 | Ecabapide | DQ2511,DQ 2511,DQ-2511 | Others |
Ecabapide (DQ-2511) is a novel gastrointestinal motility promoter that significantly enhances gastric emptying in SHRSP.Ecabapide activates cyclic GMP-dependent housekeeping Cl- channels in rabbit gastric wall cells. | |||
T68100 | Mifentidine | DA 4577 | Histamine Receptor |
Mifentidine (DA 4577) is an orally available H2 receptor antagonist for the study of gastric emptying and experimental gastric and duodenal ulcers. | |||
T1291 | Cisapride | Prepulsid,R 51619,Pridesia,Kaudalit,(±)-Cisaprid,Kinestase | Potassium Channel , 5-HT Receptor , HER |
Cisapride (R 51619) is a serotonin type 4 (5-HT4) receptor agonists are potent prokinetic agents that act on serotonin receptors in the intestine and promote intestinal peristalsis, increase gastric emptying and decrease... | |||
T21385 | Cinitapride | Paxapride,Cidine,cinitapride tartrate,Blaston,Cintapro,Cinmove | 5-HT Receptor |
Cinitapride (Blaston) is a gastroprokinetic agent. It slows the actions of the muscles to reduce the symptoms of conditions such as acid reflux, delayed gastric emptying, and ulcer dyspepsia. Cinitapride acts as an antag... | |||
T34281 | Relamorelin | BIM28131,RM 131,BIM-28131,BIM-28163,BIM 28163,BIM28163,BIM 28131 | GHSR |
Relamorelin (RM-131), a selective and potent growth hormone-releasing peptide/growth hormone secretagogue receptor (GHSR) agonist, is a potent growth hormone-releasing peptide mimetic with a high affinity for the GHS-1a ... | |||
T31214 | Dazopride fumarate | AHR-5531C | |
Dazopride fumarate is a peristaltic used to enhance gastric emptying and block emesis. | |||
T27550 | HMR-1426 | HMR 1426,HMR1426 | |
HMR-1426 is gastric emptying inhibitor. HMR1426 shows an anorectic potential in rats and decreased body weight and fat mass. This was achieved solely by reducing food intake without influencing overall energy expenditure... | |||
TP2095 | Astressin 2B | ||
Potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist (IC50 values are 1.3 and > 500 nM for CRF2 and CRF1 respectively). Antagonizes CRF2-mediated inhibition of gastric emptying. | |||
T76319 | Urocortin III (mouse) (free acid) | ||
Urocortin III (mouse) (free acid), a selective agonist with high affinity for the CRF2 receptor, significantly inhibits gastric emptying while not affecting colonic transit [1] [2]. | |||
T63237 | Acotiamide hydrochloride | ||
Acotiamide hydrochloride is a selective, orally active, reversible acetylcholine ester (AChE) inhibitor (IC50: 1.79 μM) that increases gastric contractility, accelerates delayed gastric emptying, and can be used to study... | |||
T68735 | Ciclotropium (free base) | ||
Ciclotropium (free base) is quaternary ammonium compound with anticholinergic and parasympatholytic activity. Oral Cyclotropium bromide inhibited fasting and meal-stimulated colonic motility significantly without causing... | |||
T39236 | Relamorelin acetate | Relamorelin acetate,RM-131 acetate,BIM-28131acetate | |
Relamorelin (RM-131) acetate is a pentapeptide ghrelin analog that acts as a selective agonist for the ghrelin/growth hormone secretagogue receptor (GHSR). It exhibits a high affinity for the GHS-1a receptor, with a Ki v... | |||
T76195 | Stresscopin-related peptide (human) | ||
Stresscopin-related peptide (human), a specific ligand for the type 2 CRH receptor, effectively suppresses food intake, delays gastric emptying, and decreases heat-induced edema. It plays a crucial role in maintaining ho... | |||
T22230 | Acotiamide | ||
Acotiamide is an orally active, selective and reversible acetylcholinesterase ( AChE ) inhibitor, with IC 50 of 1.79 μM. Acotiamide is a gastroprokinetic agent that enhances gastric contractility and accelerates delayed ... | |||
T83694 | Gastric Inhibitory Peptide (1-42) (porcine) TFA | GIP (1-42),Glucose-dependent Insulinotropic Polypeptide (1-42) | |
Gastric inhibitory peptide (GIP) (1-42), an endogenous incretin hormone comprising 42 amino acids, promotes insulin secretion. Expressed in the intestinal neuroendocrine K cells and submandibular gland, it enters circula... | |||
T75787 | Amylin, amide, human TFA | ||
Amylin, amide, human TFA, a 37-amino acid polypeptide, functions as a pancreatic hormone that is cosecreted with insulin, playing distinct roles in metabolism and glucose homeostasis. It regulates blood sugar by inhibiti... | |||
T75262 | Relamorelin TFA | ||
Relamorelin (RM-131) TFA, a pentapeptide ghrelin analog, acts as a potent and selective agonist for the ghrelin/growth hormone secretagogue receptor (GHSR), with a K_i of 0.42 nM for the GHS-1a receptor. This compound is... | |||
T70267 | ADL 08-0011 HCl | ||
ADL 08-0011 is an active metabolite of the μ-opioid receptor antagonist alvimopan. It is produced from alvimopan via amide hydrolysis by gut microbiota. ADL 08-0011 is a μ-opioid receptor antagonist (Ki = 0.25 nM). It is... | |||
T76263 | Beinaglutide | ||
Beinaglutide, a recombinant human GLP-1 (rhGLP-1) polypeptide, exhibits nearly complete homology with human GLP-1 (7–36). It demonstrates dose-dependent effects in improving glycemic control, reducing food intake, delayi... | |||
T35627 | Amylin (human) (trifluoroacetate salt) | ||
Amylin is a 37-residue peptide hormone secreted from pancreatic β-cells that reduces food intake, decreases glucagon secretion, slows gastric emptying, and increases satiety. It binds to amylin receptors with IC50 values... | |||
T14382 | AZD7687 | Others | |
AZD7687 is a potent and selective DGAT1 inhibitor with an IC50 value of 80 nM (hDGAT1). IC50 value: 80 nM [1] Target: DGAT1 in vitro: Plasma AZD7687 exposure was measured repeatedly. AZD7687 markedly reduced postprandial... | |||
T36373 | Urocortin II (mouse) (trifluoroacetate salt) | ||
Urocortin II is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF , urocortin , urocortin III , frog sauvagine, and piscine urotensin I.1 Mouse urocortin II... | |||
T35787 | Obestatin (human) (trifluoroacetate salt) | ||
Obestatin is a 23 amino acid peptide hormone with a conserved C-terminal glycine residue and amidation site that is formed by cleavage of the ghrelin and obestatin prepropeptide.1It binds to the orphan receptor GPR39 (Kd... |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T5S1389 | Escin IB | 5-HT Receptor , NO Synthase | |
Escin Ib inhibits gastric emptying, at least in part, mediated by capsaicin-sensitive sensory nerves, to stimulate the synthesis and/or release of dopamine, to act through central dopamine2 receptor, which in turn causes... | |||
T3727 | Methyl syringate | Syringic Acid Methyl Ester | TRP/TRPV Channel |
Methyl syringate (Syringic Acid Methyl Ester) has a unique inhibitory activity toward aflatoxin production with a different mode of action from that of gallic acid. Methyl syringate from K. pictus is a specific and selec... | |||
T5S2360 | Corydaline | Corydalin,(+)-Corydaline | P450 , Virus Protease , Opioid Receptor , AChE |
1. Corydaline (Corydalin), an isoquinoline alkaloid, is one of the major active constituents in a new prokinetic botanical agent. 2. Corydaline promotes gastric emptying and small intestinal transit and facilitates gastr... | |||
T81080 | Strictinin | ||
Strictinin, a phenolic compound extracted from Pu'er teas, exhibits antiviral, antibacterial, and laxative properties. Its mode of action involves speeding up intestinal transit without promoting gastric emptying, boosti... |
カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPH-02298 | Urocortin-3 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress. | |||
TMPH-02522 | GHRL Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid se... |